Supplements For Estrogen Metabolism
We've already mentioned that there are three main forms of estrogen: estrone, estradiol and estriol. Recall that estradiol is the most potent form of estrogen and the one that we would like to limit from excess production and activity. Of the three estrogens, estriol is the weakest.
Estrone is the form that we want to control as far as metabolism. The reason why is due to the fact that there are three further forms of "estrogen metabolites" that are made from estrone. They are 2 hydroxyestrone (2OH), 4 hydroxyestrone (4OH) and 16 alpha hydroxy estrone (16aOH). This is a complex biochemical issue but all we need to understand from our physique and health standpoint is how to limit the 4OH estrone and the 16aOH estrone. The 2OH estrone is benign in the body and is not linked with diseases like cancer and metastases.
The 16aOH estrone is mutagenic (can alter DNA unvavorably), but we can further its metabolism and excretion into a benign substance by supplying enough b-vitamins and "methyl donors". These methyl donors are nutrients that we can increase through supplementation which allow the 16aOH estrone to become the benign forms at a much higher rate and percentage. You see if we ingest enough of these "methyl donors" we push the metabolism of the 16aOH estrone further to the good "estriol" (E3).
The 4OH is carcinogenic in the breast (male and female breast) and mutagenic as is the 16aOH estrone. The great thing here is that although this sounds complex, we once again need to SIMPLY ingest more "methyl donors" and antioxidants into our diet. When we do this, the "methylated" form of 4OH becomes 4-methoxyestrone and is benign once again.
So the two bad guys are the metabolites 4OH estrone, and 16aOH estrone...both derived from the original estrone (E1). Methylators allow the metabolism of both of these mutagenic and carcinogenic substances to their benign end-point and then excreted from the body.
So what are these methylators? Here they are:
1. Vitamin B6 (pyridoxine)
2. Vitamin B12 (cyanocobalamin)
3. SAMe (s-adenosylmethionine)
4. Folic Acid
5. Vitamin B5 (pantothenic acid)
6. Indole-3-carbinol (I3C)
There are a few others, but these are great to start with. They can all be found at your nearest pharmacy, drugstore, or nutritional outlet such as VitaminWorld or GNC. They are also relatively cheap nutrients.
Bottom line adavantages to supplying these methylators: reduced cancer risk, reduced breast cancer risk (male and female), reduced prostate cancer risk, and less water and bloat on your physique. Pretty good return for a few dollars of extra supplements per month. Oh yeah, and a lifetime of constant attention to these methylators helps to reduce heavy metals in the body and brain. What is a side effect of heavy metals in the brain...altzheimer's.
What are the exact doses you need of these nutrients? Well, for now, follow what is on the label. There will be additional information in the future on how to individualize your doses for these essential methylators.