formestane drug profile
Formestane is a drug that has been previously used in breast cancer treatment. Like most drugs which have some sort of phsyique usage, athletes eventually get a hold of it. Formestane is currently one of the best legal anti-estrogens out there. It is classified as an irreversible arromatase inhibitor, meaning, it destroys the aromatase enzyme.
Another name for formestane is hydroxyandrostenedione. For those of you who don't already know, andostenedione is and always was a lousy physique supplement (or drug, whichever you like to call it). As wel all know, the even the prohormones are now illegal in the US (as of Jan 20th, 2005). Tell me how weird chemistry can be...regular androstenedione is highly aromatizable. It converts to estogen very, very readily. When it was legal and everyone was using some form of it, I heard of numerous cases of gyno from it. At the time it was legal and was an over the counter supplement. Imagine getting gyno from something that isn't even helping you build mass? That sucks.
Anyway, all formestane is, is androstenedione with one little hydroxyl (OH) group atttached at the fourth carbon. This small alteration turns a lousy physique androgen which aromatizes highly and has no real true use for us...into one of the best anti-estrogens you can obtain (legal or otherwise). Weird chemistry, huh?
Formestane has a very long active life on the order of 24-36 hours. You can get any sport supplement version capsules for around $40 US or less. This amount of $ will usually last you about 3-4 weeks at a sufficient dosage of 200-400mg per day. I have found 200mg a day to be perfect for on cycle anti-estrogen usage and for post-cycle recovery of natural testosterone. Formestane has zero negative feedback (even though it is an androgen by definition) and serves to elevate natural testosterone as well as any anti-estrogen/anti-aromatase drug out there, next to clomid.
For most users, a 100mg capsule in the morning, and another at night before bed will work well to keep a good deal of water off you. Again, it depends on your susceptibility to aromatization and what drugs and dosages of anabolics you are using. Never the less, this should suffice for most. Remember, formestane attacks the aromatase enzyme and is therefore a first line inhibitor. So if you need immediate relief of estrogen during your cycle, you need a second class drug (estrogen receptor blocker) such as nolvadex or clomid. Formestane is a lot like arimidex in its mechanism of action in attacking the aromatase enzyme itself.